Morris Lab
Principal Investigator: Quaid Morris
Institution: Memorial Sloan Kettering Cancer Center (New York, NY)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
RNA-binding proteins (RBPs) play key roles in RNA splicing, editing, nuclear export, translation, turnover, and subcellular localization. Reflecting their importance, RBPs and their cis-regulatory elements (CREs) have broad implications in human health: mutations in RBPs or CREs have well-established roles in cancer, developmental defects, particularly in neural development, and in neural degenerative diseases. Using a combination of a high-throughput, in-vitro-selection-based RNA binding assay, RNAcompete, and machine learning (ML) models trained to map from an RBP’s protein sequence to its RNA binding preferences, this project will endeavor to assign RNA sequence- and structural-context binding preferences to all human RBPs, all vertebrate RBPs, and the vast majority of metazoan RBPs. These specificities will then be used to detect and assign function to RBPs and cis-regulatory elements (CREs) in human genomes, as well as those of other model organisms. The specificities, machine learning models, and predicted CREs will be distributed widely via publication, open-source software, and user-friendly web tools like cisBP-RNA. This project has the potential to transform cancer and hu…
Active NIH Awards
- 5R01HG013328-04: Post-transcriptional Regulatory Networks (2026)
- 1R01CA318448-01: Optimization of structure-guided models of peptide presentation and T-cell receptor specificity (2026)
- 5R01HG013328-03: Post-transcriptional Regulatory Networks (2025)
- 5R01HG013328-02: Post-transcriptional Regulatory Networks (2024)
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