Petrini Lab
Principal Investigator: John Hj Petrini
Institution: Memorial Sloan Kettering Cancer Center (New York, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Our overarching goals are: i. to define the mechanism(s) of ATM activation by the Mre11 complex; ii. to define the role(s) of the Mre11 complex in DNA replication; iii. To define the role(s) of the Mre11 complex and RTEL1 in response to DNA replication stress. As noted, our focus includes RTEL1 which acts to mitigate replication stress at the telomere. A combination of yeast and mouse genetics, biochemistry, and structural biology are employed to address these issues. Our previous work on these topics led to substantial scientific progress and insight regarding processes relevant to human health. Specific areas of inquiry are: · Genetic screens in yeast and mining of cancer genomic data revealed separation of function Rad50 mutations that affect ATM dependent DNA damage signaling without affecting the DNA repair functions of the Mre11 complex. These mutations constitute a resource for deciphering the mechanism by which the Mre11 complex activates the ATM kinase to initiate DNA damage signaling. · We have obtained a cryoEM structure of the S. cerevisiae MR complex. Ongoing structural analyses of rad50S mutants offer a unique opportunity to address the mechanism of Tel1/ATM activatio…
Active NIH Awards
- 2R35GM136278-06: DNA Damage & DNA Replication: a Complex Relationship (2026)
- 5R35GM136278-05: DNA Damage & DNA Replication: a Complex Relationship (2024)
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