Root Lab
Principal Investigator: James C Root
Institution: Memorial Sloan Kettering Cancer Center (New York, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
ABSTRACT Despite significant progress in understanding cognitive change associated with cancer and cancer treatments, little is known regarding longer-term cognitive outcomes over developmentally meaningful intervals in older age (5-20 years post-treatment) and potential association with frailty. Previous work from our lab and others, focusing on the direct effects of cancer and cancer treatment, has moved the field forward for a better understanding of these direct effects but is limited with regard to tracking long-term cognitive trajectories due to 1) focus on cognition before and after treatment and short intervals following treatment completion; 2) longitudinal designs that introduce practice effects and selective attrition that distort true cognitive trajectories; and 3) short intervals that also limit the ability to assess accumulation of deficits, i.e., frailty, to potentially associate with cognitive declines. We will assess cognition in 210 cancer survivors diagnosed between 55 and 60 years of age and 210 non-cancer controls at three cross-sectional age bands: 65-69; 70-74; 75-80. Cognitive assessment will consist of online, remote administration of a validated platform o…
Active NIH Awards
- 5R01CA276265-04: Cognitive aging in long-term breast cancer survivors (2026)
- 5R01CA276265-03: Cognitive aging in long-term breast cancer survivors (2025)
- 5R01CA276265-02: Cognitive aging in long-term breast cancer survivors (2024)
Explore 700+ US Biology Labs on FindBioLabs.com