Berner Lab
Principal Investigator: Laura A. Berner
Institution: Icahn School of Medicine at Mount Sinai (New York, NY)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT Bulimia nervosa (BN) is a disabling and often chronic eating disorder associated with medical complications and premature death. There is an acute need to identify the mechanisms that maintain BN and that may serve as targets for new treatments. Most studies have assumed that BN is perpetuated by stable, trait-like factors, including self-reported impulsivity and deficits in the ability to exert cognitive control. However, the out-of-control excessive intake and compensatory behaviors characteristic of BN are episodic and tend to alternate with periods of restricted intake or even fasting, suggesting intermittent oscillations in control. In addition, emerging work in behavioral economics and cognitive neuroscience suggests that failures to ultimately exert cognitive control depend on numerous neural computations, including: updating predictions about whether control will be needed in the next moment, and deciding whether trying to exert control is worth the costly cognitive effort. The overarching goal of this R01 is to clarify how these cognitive control computations may fluctuate across fasted and fed states in BN, potentially maintaining the cyclical nat…
Active NIH Awards
- 5R01MH132786-04: Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa (2026)
- 1R01DK143232-01A1: The Interaction between Food Craving and Food Choice in Humans: A Computational Intracranial Electrophysiological Study (2026)
- 5R01MH132786-03: Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa (2025)
- 5R21MH129898-02: The Computational Role of Corticostriatal Circuits in Binge-Eating Disorder Symptoms and Severity (2024)
- 5R01MH132786-02: Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa (2024)
Explore 700+ US Biology Labs on FindBioLabs.com