Chipuk Lab
Principal Investigator: Jerry Edward Chipuk
Institution: Icahn School of Medicine at Mount Sinai (New York, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY The impact of mitochondrial biology on human cancers is broad because these organelles are critical regulators of metabolism, proliferation, metastasis, and cell death. Indeed, mitochondrial aberrations are common in multiple cancer types – not only do mitochondrial dysfunctions correlate with disease pathogenesis, but aberrant mitochondria also negatively impact upon chemotherapeutic success. Within a cell, mitochondrial homeostasis is maintained by a process referred to as “mitochondrial dynamics”, which is essential for efficient ATP generation, mitochondrial metabolites/substrates distribution, and mitochondrial DNA (mtDNA) integrity. Homeostatic mitochondrial dynamics result from the cumulative nature of complementary cycles of mitochondrial division and fusion. Work from my laboratory demonstrates: (1) the mitochondrial division machinery is essential for cellular transformation, (2) mitochondrial division is chronically activated in RAS-transformed murine cells and human cancer lines harboring oncogenic mutations within the MAPK pathway, (3) chronic mitochondrial division is sufficient to initiate mitochondrial dysfunction and cancer cell metabolism, and (4)…
Active NIH Awards
- 5R01CA271346-04: The Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence Biology (2026)
- 5R01CA267696-05: Chronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and Therapy (2026)
- 5R01CA271346-03: The Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence Biology (2025)
- 5R01CA267696-04: Chronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and Therapy (2025)
- 5R01CA237264-05: Function and Regulation of the BCL-2 Family (2024)
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