Chuang Lab
Principal Investigator: Ling-Shiang Chuang
Institution: Icahn School of Medicine at Mount Sinai (New York, NY)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT ABSTRACT This proposal is submitted in response to FOA RFA-DK-21-022, to serve as a Genetics Research Center (GRC), within the NIDDK Inflammatory Bowel Disease (IBD) Genetics Consortium (IBDGC), at the Icahn School of Medicine at Mount Sinai, New York. During the present period, we made substantive progress in defining mechanisms of anti-TNF non-response in ileal Crohn’s disease and defined the role of NOD2 mutations in altering blood monocyte differentiation to result in an aberrant myeloid-stromal niche. In this proposal, we seek to expand on the role of blood monocyte differentiation, but newly-focused on perianal fistulae, a major unmet medical need in Crohn’s disease, conferring substantial morbidity. Single cell transcriptomics has provided enormous insight into molecular mechanisms in IBD; our lab has substantial expertise in this and will leverage new approaches including multiome ATAC + transcriptome and higher resolution spatial transcriptomics platforms available soon. Aim 1 will focus on direct ex-vivo single cell analyses involving perianal fistulae including all Crohn’s disease patients. Aim 2 will expand in vitro analyses focusing on rectal-derived enteroids…
Active NIH Awards
- 5U01DK062422-27: Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations (2026)
- 5U24DK062429-27: Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBD (2026)
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