Schwartz Lab
Principal Investigator: Gregory William Schwartz
Institution: Northwestern University (Chicago, IL)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Among the 5 classes of neurons in the mouse retina (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and retinal ganglion cells), our field has achieved complete or nearly complete classifications of all but the amacrine cells. One goal of this project is to fill part of this gap in knowledge by establishing a multimodal classification of displaced amacrine cells (dACs). However, unlike many other types of neurons, amacrine cells (ACs) either have no axons or they have multiple axons that may transmit different information to different locations. Thus, a second goal of this project is to go beyond somatic recordings to measure the subcellular compartmentalization critical to revealing the role amacrine cells play in retinal circuits. We have measured light responses, intrinsic electrical properties, and morphology from over 100 dACs and clustered them into 21 types. In Aim 1, we will align these morpho-electric types to transcriptomic clusters from the published single-cell RNA-seq databases. In Aims 2 and 3, we will use two-photon calcium imaging to measure functional compartmentalization within dAC neurites. The successful completion and publicatio…
Active NIH Awards
- 5R01EY036978-02: Multimodal classification and sub-cellular compartmentalization of displaced amacrine cells in the mouse retina (2026)
- 5R21EY036157-02: Measuring retinal ganglion cell spike responses in the intact perfused eye following optic nerve injury (2025)
- 1R01EY036978-01: Multimodal classification and sub-cellular compartmentalization of displaced amacrine cells in the mouse retina (2025)
- 5R01EY031329-05: Functional consequences of heterotypic retinal ganglion cell coupling (2024)
- 1R21EY036157-01: Measuring retinal ganglion cell spike responses in the intact perfused eye following optic nerve injury (2024)
Explore 700+ US Biology Labs on FindBioLabs.com