Woloschak Lab
Principal Investigator: Gayle E. Woloschak
Institution: Northwestern University (Chicago, IL)
Primary Subfield: Immunology
Recruitment Status: ✅ Accepting PhD Students
Research Focus
PROJECT 3: ABSTRACT The overall objective of Project 3 is to link radionuclide exposure and the elemental signature left behind with biomarkers of that exposure, be they histological, cellular or molecular in nature. Our motivation to do this stems from the fact that radiation from internal emitters is very unevenly distributed in organs, tissues, and cells and the fact that this remains little understood. Heterogeneity of radionuclide distribution is dependent upon a complex set of parameters that relate to the radionuclide itself and the organism’s response to it, such as radionuclide half-life, decay schema, activity, concentration, particle size, morphology, chemical form, and solubility, whereas the biological response patterns are dictated by the genotype and phenotype of the cells, tissues and organs, intake route and the organism as a whole. Because the in vivo footprint of radionuclide exposure is multi-scale, e.g., DNA damage and cell death at the (sub)cellular level, or chemokine/cytokine production at the cell/tissue level, it essentially means that biomarkers of that exposure are best registered along the same multi-dimensional NANO-, MICRO- and MESO scale, which is ou…
Active NIH Awards
- 5P01AI165380-05: Project-003 (2026)
- 5P01AI165380-05: Multi-Scale Evaluation and Mitigation of Toxicities Following Internal Radionuclide Contamination (2026)
- 5P01AI165380-05: Admin-Core-001 (2026)
- 5P01AI165380-05: Core-001 (2026)
- 5P01AI165380-05: Project-002 (2026)
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