Boeke Lab
Principal Investigator: Jef D Boeke
Institution: New York University (New York, NY)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Summary Methods for rapidly generating synthetic nucleic acid constructs have dramatically changed biological and biomedical research. Improvements in these arenas will continue to affect many areas of genomics and biomedicine such as synthetic genomics and associated functional screens. Enabling significant advances with new nucleic acid synthesis and synthetic construct capabilities has the potential to lead to remarkable improvements in the understanding, diagnosis, treatment and prevention of disease; advances in agriculture, environmental science and remediation; and understanding of evolution and ecological systems. Current abilities to work with a variety of synthetic constructs have been enabled by cost reductions in oligonucleotide synthesis along with vastly improved techniques for hierarchical assembly of larger constructs, largely in yeast. Our group has led the way both in assembling the yeast genome (i.e. the international Sc2.0 project) and in a NHGRI-sponsored CEGS that has launched the “Dark Matter Project”, which aims to functionally dissect noncoding DNA and its contribution to human/mammalian transcriptional regulation. This renewal proposal seeks to support ong…
Active NIH Awards
- 2R01HG012743-04: The Assemblatron-Renewal (2026)
- 5RM1HG009491-09: CEGS: Center for Synthetic Regulatory Genomics - Renewal (2026)
- 5U19AI191396-02: PROJECT 1 (2026)
- 5R24OD037800-02: Genomically rewritten and tailored humanized mouse models for various organ disorders (2026)
- 3OT2CA278666-01S4: eDyNAmiC - NYU (2026)
Explore 700+ US Biology Labs on FindBioLabs.com