Eisfeld Lab
Principal Investigator: Ann-Kathrin Eisfeld
Institution: The Ohio State University (Columbus, OH)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Acute myeloid leukemia (AML) is the most common adult acute leukemia. Molecular features such as cytogenetics and somatic mutations are essential components of risk stratification; used in daily clinical practice to determine treatment modality and intensity. Our knowledge of recurrent genetic AML-associated features, survival associations, subsequent genetic risk classification and clinical practice is informed by large-scale genomic studies performed over the past decade. Current clinical practice is predicated on the supposition that adequate testing has been performed and that genetic background should not interplay with the known AML-associated genetic and genomic landscape or with genes that associate with treatment response and/or that drive AML-genesis. However, our published and preliminary data reveal that constitutional genetic elements affect not only the frequencies and impact of known AML-associated gene mutations, but also multiple recurrent variants in genes thus-far not implicated in AML-genesis. We hypothesize that: a) known AML-associated drivers may carry different prognostic significance and might need to be adjusted in clinical risk classifications depending o…
Active NIH Awards
- 5R01CA284595-04: Towards a more generalizable genomic risk classification for acute myeloid leukemia (AML) (2026)
- 5R01CA262496-04: Understanding Treatment Response Patterns And Therapy Resistance In IDH-Mutant AML (2026)
- 5R01CA284595-03: Towards a more generalizable genomic risk classification for acute myeloid leukemia (AML) (2025)
- 5R01CA284595-02: Towards an inclusive genomic risk classification for acute myeloid leukemia (AML) (2024)
- 5R01CA262496-03: Understanding Treatment Response Patterns And Therapy Resistance In IDH-Mutant AML (2024)
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