Gumina Lab
Principal Investigator: Richard J Gumina
Institution: The Ohio State University (Columbus, OH)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease of unclear pathogenesis that remains the leading cause of morbidity and mortality throughout the world. Immune responses play a central role in the evolution of this chronic disease, and CD4+CD25+Foxp3+ regulatory T cells (Tregs) exhibit critical functions to regulate inflammation. We have shown the level of expression of CD39, an immunosuppressive ectonucleotidase, on Tregs to be genetically associated in humans with specific single nucleotide polymorphisms (SNPs). Although select SNPs for CD39 have been linked to Crohn disease, no studies have examined whether alterations in Treg CD39 catalytic activity, and changes in extracellular ATP scavenging with adenosine generation, impact manifestations of ASCVD. Similarly, a naturally occurring antisense ENTPD1-AS1 has been shown to decrease CD39 expression in Crohn’s patient Tregs. Inhibition of ENTPD1-AS1 with a specific self- delivering FANA CD39 antisense (FANA-CD39-AS) oligonucleotide were shown to increase CD39 expression, providing a therapeutic option to modulate Treg phenotype. Our overall experimental goal is to elucidate the impact of ge…
Active NIH Awards
- 5R01HL167511-04: Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease (2026)
- 5R01HL174049-03: Genetic modulation of inflammation following myocardial infarction (2026)
- 5R01HL167511-03: Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease (2025)
- 5R01HL174049-02: Genetic modulation of inflammation following myocardial infarction (2025)
- 5R01HL167511-02: Influence of T cell genotype/phenotype in atherosclerotic cardiovascular disease (2024)
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