Herman Lab
Principal Investigator: Paul K Herman
Institution: The Ohio State University (Columbus, OH)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
The eukaryotic cell is a highly compartmentalized structure that is subdivided into distinct functional areas by the presence of both membrane-bound and membraneless organelles. These latter compartments have also been referred to as biomolecular condensates. Although most of these membraneless structures have been identified only recently, condensate formation has been found to be important for many essential processes in the cell. It is therefore critical that we develop a thorough understanding of the mechanisms underlying condensate formation and the nature of their biological activities in the cell. We have been addressing these broader issues by studying the biology of one particular condensate, the Processing body, or P-body. This cytoplasmic granule is highly conserved and contains translationally- repressed mRNAs and proteins involved in the processing of these transcripts. Our efforts over the past 15 years have been focused on developing a better understanding of the physiological roles of these granules in the eukaryotic cell. Studies during the prior grant period furthered this understanding by identifying a potential role for P-bodies in the regulation of microtubule…
Active NIH Awards
- 5R01GM128440-08: An analysis of the regulation and functions of a novel family of membraneless organelles in eukaryotic cells (2026)
- 5R01GM128440-07: An analysis of the regulation and functions of a novel family of membraneless organelles in eukaryotic cells (2025)
- 5R01GM128440-06: An analysis of the regulation and functions of a novel family of membraneless organelles in eukaryotic cells (2024)
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