Jackman Lab
Principal Investigator: Jane Elizabeth Jackman
Institution: The Ohio State University (Columbus, OH)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY/ ABSTRACT Transfer RNAs (tRNAs) are the universal adaptor molecules necessary to convert the nucleic acid-based genetic code into protein sequence during protein synthesis (translation) by the ribosome. This process is universally conserved and fundamental to all life, and, as such, defects in the molecular players of translation, including tRNAs, result in diverse human diseases. Specific chemical modifications such as methylation are common in tRNA, but a detailed understanding of the enzymes that incorporate them and their contributions to tRNA function (and disfunction in disease) have only recently emerged for a few select examples. Since the discovery of the tRNA methyltransferase (Trm10) in Saccharomyces cerevisiae, an accumulating body of evidence, including phenotypes in yeast and a multisymptomatic disease associated with human mutations, has established a significant role for Trm10 in tRNA biology. To better understand the implications of Trm10 modification, the mechanisms by which Trm10 family enzymes specifically recognize and act on their substrate tRNA, and the impact of tRNA modifications on important cellular processes need to be addressed. This pro…
Active NIH Awards
- 5R01GM130135-08: Mechanisms and biological functions of SPOUT methyltransferases (2026)
- 5R01GM130135-07: Mechanisms and biological functions of SPOUT methyltransferases (2025)
- 5R01GM130135-06: Mechanisms and biological functions of SPOUT methyltransferases (2024)
- 3R01GM130135-05S1: Mechanisms and biological functions of SPOUT methyltransferases (2024)
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