Oghumu Lab
Principal Investigator: Steve Onyeka Oghumu
Institution: The Ohio State University (Columbus, OH)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Oral cancer is a significant public health problem, as 58,450 new cases and 12,230 deaths occur annually. in the United States. Despite treatment advances, the overall survival rates (60% at 5 years, 50% at 10 years) for oral cancers have not appreciably changed over the past 30 years. Therefore, new and effective oral cancer chemoprevention and treatment strategies are needed. Although synthetic glucocorticoids are routinely used as adjuvant therapy in postoperative oral cancer patients, recent evidence indicates that glucocorticoids may actually promote tumor progression in some cases, thereby challenging the use of these compounds in patients with premalignant and malignant oral disease. Since glucocorticoid biosynthesis and regulation can occur in the oral mucosa, it is essential that we clearly understand the role of the oral glucocorticoid system on oral cancer development and metastasis. Further, we recently identified a potent cancer chemopreventive agent, gallic acid, which modulates glucocorticoid metabolism, but specific mechanisms associated with gallic acid mediated regulation of glucocorticoid metabolism during oral cancer chemoprevention is currently…
Active NIH Awards
- 5R01DE033906-03: The oral glucocorticoid system in oral carcinogenesis and its modulation for improved treatment outcomes (2026)
- 5DP1DA054344-05: X chromosome inactivation in sex disparities to substance use disorder (2026)
- 5R01DE033906-02: The oral glucocorticoid system in oral carcinogenesis and its modulation for improved treatment outcomes (2025)
- 5DP1DA054344-04: X chromosome inactivation in sex disparities to substance use disorder (2025)
- 5DP1DA054344-03: X chromosome inactivation in sex disparities to substance use disorder (2024)
Explore 700+ US Biology Labs on FindBioLabs.com