Hargreaves Lab
Principal Investigator: Diana Clare Hargreaves
Institution: Salk Institute for Biological Studies (La Jolla, CA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Developing immunological memory is crucial for surviving deadly pandemics and while a better understanding of how memory B and T cells form and function is being gained, there are still many gaps in knowledge that limit our ability to create superior vaccines for several pathogens and new immunotherapies. CD8+ T cells differentiate into heterogeneous subsets that display diverse functions, migration patterns and long- term fates to protect against recurrent viral infection. How CD8+ T cells toggle between less-, intermediate- and terminally-differentiated states remains a major question because this can influence the number and quality of memory T cells that form. Great progress has been made in identifying transcription factors (TFs) and epigenetic writers and erasers that control CD8+ T cell differentiation states, particularly the long-lived, multi-potent memory precursor (MP) cells and shorter-lived, terminally-differentiated effector (TE) cells. But it is unclear what determines which enhancers open and close to permit the targeting of these factors to specific loci that ultimately creates the molecular foundation for a range of gene expression patterns and dif…
Active NIH Awards
- 5R01AI066232-22: Regulation of memory CD8 T cell development (2026)
- 5R01CA285867-03: The Role of the Tumor Suppressor ARID1A in R loop Homeostasis and Tumor Immunity (2026)
- 5R01CA285867-02: The Role of the Tumor Suppressor ARID1A in R loop Homeostasis and Tumor Immunity (2025)
- 1R01CA285867-01: The Role of the Tumor Suppressor ARID1A in R loop Homeostasis and Tumor Immunity (2024)
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