Maher Lab
Principal Investigator: Pamela Anne Maher
Institution: Salk Institute for Biological Studies (La Jolla, CA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Abstract: There are no effective treatments for age-dependent neurodegenerative conditions such as Alzheimer's disease (AD). To address this major public health crisis, the National Alzheimer's Project Act (NAPA) was passed to “find effective interventions to treat and prevent AD and related dementias by 2025.” To achieve this goal in 5 years one or more effective drugs are required, likely sourced from repurposed drugs that are the basis of this application. Dementias are diseases that occur with age. Therefore, aging must be incorporated into the drug target validation strategy to ensure that the target mechanism remains active in aged individuals and to facilitate an understanding of the interaction between aging and AD. The recognition of this fact led to the NOT-AG-18-051 initiative with one goal of “employing a lifespan approach to understand the mechanisms of protective and risk factors” for AD. In this application, we formally address the goals of both initiatives by integrating lifespan studies with an age-related phenotypic screening platform that has yielded compounds that extend lifespan (geroprotectors), one of which is now in AD clinical trials. During the last decade…
Active NIH Awards
- 5R01AG069206-05: Using geroscience to understand and treat Alzheimer's disease (2024)
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