Briney Lab
Principal Investigator: Bryan Briney
Institution: Scripps Research Institute (La Jolla, CA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Arenaviruses are a family of zoonotic RNA viruses that can cause severe hemorrhagic fever disease in humans. There have been several instances of zoonotic crossover into humans over the past several decades, and emerging variants of known arenaviruses often display increased human-to-human transmissibility and broader geographic range. The World Health Organization and the United States Centers for Disease Control and Prevention have classified several human arenaviruses as high priority pathogens. Lassa virus (LASV), an Old World arenavirus which is endemic in regions of West Africa including Sierra Leone and is the causative agent of Lassa fever (LF), causes thousands of deaths annually. LASV is a global threat as well: the PREDICT consortium ranked LASV as the highest risk virus on their watchlist of potential pandemic pathogens. Broadly effective arenavirus vaccines and therapeutics are urgently needed; however, we must first gain a much deeper understanding of the molecular mechanisms that result in protective humoral immunity. This project focuses on leveraging innovative, high-throughput antibody discovery and characterization tools to define the genetic, functional and stru…
Active NIH Awards
- 5R01AI171438-05: Genetic, structural and functional profiling of the human antibody response to arenavirus infection (2026)
- 5P01AI177683-04: The Multi-omics Vaccine Evaluation (MOVE) Consortium (2026)
- 5P01AI177683-04: Project 2: Immune Response Analysis (2026)
- 5R01AI192456-02: Engineering durable immunity by optimizing HIV vaccine parameters to drive long-lived plasma cell development (2026)
- 5P01AI177683-04: Admin Core (2026)
Explore 700+ US Biology Labs on FindBioLabs.com