Huang Lab
Principal Investigator: Mia L Huang
Institution: Scripps Research Institute (La Jolla, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Glycoproteins and proteoglycans are important protein glycoconjugates in the cell. They can control many biological events, such as growth factor signaling, cell adhesion, and differentiation, to impact cancer biology, development, and immunity. While vital to human health and physiology, we currently do not have a comprehensive molecular understanding of how these molecules orchestrate their functions. Many techniques study these molecules in isolation – focusing on only the protein or glycan component alone. This current approach severely underappreciates the structural diversity of protein glycoconjugates, and it has left us with a narrowed understanding of how protein glycoforms can differentially regulate biology. Furthermore, it has impeded pathways to use glycoform-dependent interactions for drug discovery. Our research program integrates techniques in chemical biology, molecular biology, and protein engineering, in order to address these gaps. In this application, we describe our prior successes in addressing these problems and how our new insights, which were developed from these studies, will be expanded and refined to further create avenues to define glyc…
Active NIH Awards
- 2R35GM142462-07: Bridging the Glycome and Proteome with Chemical Biology (2026)
- 1R21HD119928-01: Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis (2025)
- 5R21AI178437-02: Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc (2025)
- 5R35GM142462-06: Bridging the Glycome and Proteome with Chemical Biology (2025)
- 5R35GM142462-05: Bridging the Glycome and Proteome with Chemical Biology (2024)
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