Seiple Lab
Principal Investigator: Ian Seiple
Institution: Scripps Research Institute (La Jolla, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary/Abstract This proposal summarizes ongoing projects in our laboratory focused on natural product classes that have promising biological activity but are burdened with limitations that have prevented them from reaching their therapeutic potential. These classes are structurally complex and modification of their is challenging by semisynthetic and biosynthetic methods. We aim to develop fully synthetic routes to these classes from simple building blocks, enabling chemical modification to overcome their limitations. These efforts are informed by binding data (X-ray or cryo-EM) for each class. The primary goals of project outlined herein are to 1) expand structure–function relationships for each of these important classes of molecules, and 2) discover potent analogs that are suitable for hit-to-lead optimization or for use as tools to study biological systems. Additionally, development of the synthetic routes themselves is highly innovative, and is often accompanied by development of methods that are broadly applicable in chemistry. These efforts mirror our work on streptogramin and lankacidin antibiotics, which was a primary focus in our Early Stage Investigator MIRA (R…
Active NIH Awards
- 5R35GM148184-05: Modular synthesis of antibiotic and anticancer classes of natural products (2026)
- 5R35GM148184-04: Modular synthesis of antibiotic and anticancer classes of natural products (2025)
- 7R35GM148184-03: Modular synthesis of antibiotic and anticancer classes of natural products (2024)
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