Teyton Lab
Principal Investigator: Luc Teyton
Institution: Scripps Research Institute (La Jolla, CA)
Primary Subfield: Immunology
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Abstract While our PO1 aims at positioning anti-glycan immunotherapy as a new approach to treat severe bacterial diseases, we will contribute some essential basic studies to it by deconstructing the immune recognition of glycans by T and B cells. This work is made possible by the chemistry groups (Projects 1, 2, and 3) who will provide unique immunogens and reagents and will fit next to the bacteriology and structural biology components of the consortium to perform in vivo studies and structure determinations. The integration of the immunology results within this framework will inform the chemists on how to modify glycan epitopes and their linkages to optimize immune recognition and in vivo effector functions. Our effort will be divided between three specific aims: Aim 1: Establish the molecular basis of glycan recognition by T cells. We have shown that cognate recognition of the glycopeptide (GP) by T cells occurred. We will determine its importance in driving high affinity anti-glycan antibodies and study the repertoire diversity of these cells. The biophysical and structural basis of MHC-GP T cell recognition will be examined as well. We hypothesize that cognate glycan recogniti…
Active NIH Awards
- 5P01AI172525-04: Multidimensional development of high-affinity anti-glycan antibodies to fight deadly bacterial infections (2026)
- 5P01AI172525-04: Molecular basis of glycan recognition by T and B cells (2026)
- 5P01AI172525-04: Antibody Core (2026)
- 5R01DK143190-02: Initiation of anti-islet autoimmunity: Regulation of MHC class II expression in the islet microenvironment (2026)
- 1R01AI198771-01: Mechanistic Studies of Combination Adjuvants in the Establishment of B Cell Memory (2026)
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