Engreitz Lab
Principal Investigator: Jesse M Engreitz
Institution: Stanford University (Stanford, CA)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Genome-wide studies have now identified hundreds of thousands of associations between genes or genetic loci and human phenotypes, each of which could reveal mechanistic insights about disease biology. Yet, the cell-type specific functions of most of these genes remain unknown, and we currently lack the ability to connect these genes into cellular programs and thereby reveal the pathways important for disease. To address this limitation, our proposed Data Analysis and Validation Center aims to work together with the MorPhiC Consortium to build a Catalog of Cellular Programs — i.e. a map of which genes work together in biological pathways and their corresponding multimodal molecular and cellular phenotypes, in defined cell types or states. Our team brings a diverse set of expertise in computational genomics, methods and technology development, experimental design, interdisciplinary collaboration, consortium organization; and includes new junior investigators who will bring new forward-thinking ideas and tools to MorPhiC. We have developed a wave of innovative methods integrating CRISPR, single-cell, imaging, and human genetics data that will enable building such a Cat…
Active NIH Awards
- 5U01HG013176-04: MorPhiC: Constructing a Catalog of Cellular Programs to Identify and Annotate Human Disease Genes (2026)
- 1R01HL184893-01A1: An integrative genomics toolkit for rewriting regulatory DNA to reprogram gene expression (2026)
- 5P01HL180323-02: Scientific Core: Perturb-seq library generation, sequencing, and data analysis (2026)
- 1R01HG014216-01: Genome-wide maps of enhancer-gene regulation to link variants to functions (2026)
- 5R01HL171609-03: Mapping, programming, and correcting gene regulatory sequences for Alagille Syndrome (2026)
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