Gozani Lab
Principal Investigator: Or P. Gozani
Institution: Stanford University (Stanford, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
ABSTRACT Covalent post-translational protein modifications (PTMs) contribute to all aspects of cell physiology and are a major source of protein functional diversity in mammalian cells. Aberrant regulation of PTMs is a common feature of human diseases. Our research focuses on an important PTM: protein methylation occurring on lysine residues as well as on less common residues. Our overarching goal is to elucidate at a molecular level the physiologic roles for protein methylation signaling in the regulation of chromatin biology, epigenetics, protein synthesis, and other fundamental biological processes, and to understand how disruption in these mechanisms contributes to human disease. Within this research framework we will investigate the biology and function of enzymes that regulate histone methylation dynamics, with a focus on methylation at histone H3 lysine 36 (H3K36). Beyond histone methylation, there is a growing appreciation that a number of non-histone proteins, including several with clear roles in gene expression and signal transduction are lysine methylated. Indeed, there are likely more than seventy-five lysine methyltransferases in the human genome, and an increasing nu…
Active NIH Awards
- 2R35GM139569-06: Function of Protein Methylation in Chromatin and Signaling Regulation (2026)
- 5R35GM139569-05: Function of Protein Methylation in Chromatin and Signaling Regulation (2025)
- 5R35GM139569-04: Function of Protein Methylation in Chromatin and Signaling Regulation (2024)
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