Mackall Lab
Principal Investigator: Crystal Mackall
Institution: Stanford University (Stanford, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Since the 1990s, pediatric oncology has made sustained strides in understanding the biology that drives children’s cancers, but these understandings have not yielded significant therapeutic gains. Approximately 20% of children diagnosed with cancer today are not cured with current standard regimens and cancer remains the leading cause of disease related death in children in the US and other high-income countries. Nearly all current standard treatments are cytotoxic regimens, which are associated with shortened lifespans, high rates of severe late effects and second malignancies and diminished quality of life. There is an urgent need to develop safer and more effective, targeted therapeutics for treatment of children’s cancers. During the last three decades, the Mackall lab has made sustained contributions to a growing body of evidence demonstrating that immunotherapies can selectively target even the most aggressive cancers, raising the prospect that immunotherapies specifically designed for children’s cancers could improve cure rates and diminish toxicity. This program will build upon deep understandings of fundamental cellular and molecular immunology in the Macka…
Active NIH Awards
- 5R35CA283888-03: Next Generation Immunotherapies for Pediatric Cancers (2026)
- 5P01CA049605-35: Designing Chimeric Antigen Receptor Therapies to Overcome Treg Suppression (2026)
- 5U01CA281865-04: Attacking the Immunopeptidome of Ewing Sarcoma (2026)
- 5P30CA124435-18: Cancer Immunotherapy (2026)
- 4UH3CA297747-03: Next Generation GPC2-CARs for Medulloblastoma (2026)
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