Rosenberg Lab
Principal Investigator: Noah Rosenberg
Institution: Stanford University (Stanford, CA)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Population-based studies identifying the genetic variants that affect complex human diseases have relied heavily on population-genetic principles in important tasks such as study design, quality control, and genotype imputation. The dramatic growth of large-scale genotyping and sequencing studies of disease generates new challenges both for modeling the underlying generative population-genetic processes that give rise to evidence of disease association in data sets and for performing statistical analysis to uncover disease variants. These challenges magnify the potential for approaches grounded in population genetics to maximize the return from ongoing investigations. This project builds on productive efforts in two previous funding periods, capitalizing on the study of human population genetics to enhance the design, analysis, and interpretation of genomic studies of disease. It exploits the fundamental principle of human genetics that population-genetic phenomena are responsible for homozygous placement of recessive risk variants, and the recent recognition that accumulations of runs of homozygosity (ROH), and hence, of multiple recessive deleterious variants of small effect in h…
Active NIH Awards
- 5R01HG005855-14: Population genetics for large-scale sequencing studies (2026)
- 5R01HG005855-13: Population genetics for large-scale sequencing studies (2024)
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