Duarte Lab
Principal Investigator: Audrey Duarte
Institution: The University of Texas at Austin (Austin, TX)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT Emerging evidence suggests that age and depression, even the modest levels common in aging, may interact to produce a “double jeopardy” for episodic memory impairment and may predict cognitive decline and Alzheimer’s disease (AD). The underlying cause/s of this double jeopardy is unknown. Even less is known about depression- related memory impairments in Black/African American and Mexican Americans, despite evidence of more disabling depression, and AD prevalence than in non-Hispanic Whites (NHWs). Multiple race-related proxy factors (e.g., discrimination, vascular burden, religiosity) that may exacerbate or reduce depression-related memory impairments but they have seldom been explored. Executive dysfunction may be an important contributor to depression-related episodic memory impairments but studies of depression-related memory and executive functioning impairments have been conducted in parallel. We propose a new conceptual framework in which depression-related executive and associated PFC dysfunction underlie depression-related memory impairments, double jeopardy effects, and ethnoracial disparities in these impairments. We will enroll 330 adults from B…
Active NIH Awards
- 5R01AG084235-03: Executive contributions to the “double jeopardy” of depressive symptoms and age on episodic memory. (2026)
- 5R01AG084235-02: Executive contributions to the “double jeopardy” of depressive symptoms and age on episodic memory in racially diverse adults (2025)
- 1R01AG084235-01A1: Executive contributions to the “double jeopardy” of depressive symptoms and age on episodic memory in racially diverse adults (2024)
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