Hu Lab
Principal Investigator: Linden T Hu
Institution: Tufts University (Boston, MA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
ABSTRACT: Project 2, Immunology of Post-treatment Lyme Disease Syndrome Similarities between symptoms of Post-Treatment Lyme Disease Syndrome (PTLDS) and symptoms seen with fibromyalgia, auto-immune diseases and post-acute sequelae of other infectious diseases are suggestive of a shared common pathway underlying the symptoms. Immune responses to different stimuli may activate similar pathways and have long been suspected as a culprit in these syndromes. Prior studies of patients with PTLDS have shown evidence of specific immune activation when compared with subjects that have recovered from Lyme disease-- although these studies have been inconsistent between different studies. Multiple auto- antibodies have been identified after infection with Lyme disease however the association for any specific auto- antibody remains undetermined. Antibodies from patients with PTLDS vs recovered Lyme disease have been shown by one group to bind to neural tissue suggesting a possible mechanism for the persistence of symptoms. In this Project, we will utilize samples collected by our Clinical Coordination Core to compare responses between patients with PTLDS and recovered Lyme disease. In Aim 1, we…
Active NIH Awards
- 5P01AI181934-03: Immunology of Post-Treatment Lyme Disease Syndrome (2026)
- 3P01AI181934-03S1: A Prospective Study of Persistent Symptoms of Lyme Disease (2026)
- 5P01AI181934-03: Administrative Core (2026)
- 5P01AI181934-03: A Prospective Study of Persistent Symptoms of Lyme Disease (2026)
- 5P01AI181934-03: Microbiology of Post-Treatment Lyme Disease Syndrome (2026)
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