Tarantal Lab
Principal Investigator: Alice F Tarantal
Institution: University of California, Davis (Davis, CA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY / ABSTRACT This application is submitted in response to RFA-RM-24-007 with the overriding objective of providing validated assays to understand the immunology of gene editors in pre-clinical studies supporting investigational new drugs (INDs) and eventually in clinical trials. Immunomonitoring is critically important to ensure safety as gene editing therapies transition to the clinical setting for a wide range of applications and diseases. The goals of these studies will be accomplished through the following Specific Aims: (1) Validate a cytokine flow cytometry assay measuring T-cell immunity to commonly used gene editors, vectors, and related peptides from the human peptidome; and (2) Provide a validated multiplex assay for binding antibodies against the domains of relevant gene-editing proteins. We will validate these assays by demonstrating accuracy, precision, specificity, linearity, and range with Quality Assurance monitoring. The assays proposed are based on cytokine flow cytometry and the adaptation of a multiplex microbead immunoassay to accommodate multiple antigens of interest for genome editors being tested for future human use. We will also track the imp…
Active NIH Awards
- 4U01AI191209-02: Validated Immunoassays to Accelerate Therapeutic Genome Editing INDs (2026)
- 5R01OD036239-03: Enhancing Rigor and Reproducibility of Translational Nonhuman Primate Models for Genetic and Regenerative Therapies (2026)
- 5R01HD107737-03: Impact of Maternal Inflammation and Cell Trafficking on Fetal Immune Ontogeny (2026)
- 5R24OD034056-04: Translational Nonhuman Primate Regenerative Medicine and Gene Therapy/Genome Editing Resource Program (2026)
- 1U01AI191209-01: Validated Immunoassays to Accelerate Therapeutic Genome Editing INDs (2025)
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