Kline Lab
Principal Investigator: Justin Paul Kline
Institution: University of Chicago (Chicago, IL)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Outcomes for patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) remain poor despite recent therapeutic advances, particularly in the area of immunotherapy. Classification of solid tumor microenvironments as immune “inflamed” or “non-inflamed” through bulk transcriptional profiling enriches for a subset that is checkpoint blockade therapy (CBT) responsive. Conversely, the DLBCL immune landscape has not been as well-characterized, and the extent to which immune environmental features can predict for immunotherapy response in DLBCL patients is unknown. Given that a growing number of immunotherapies are being explored in the relapsed/refractory DLBCL space, a deeper understanding of the DLBCL immune landscape might uncover clues that aid in identifying patients likely to benefit from checkpoint blockade and/or CAR T cell therapies. Additionally, growing evidence indicates that cancer cell-intrinsic alterations can profoundly affect the tumor immune environment, which directly impacts immunotherapy sensitivity. How recurring genetic alterations and related pathways in malignant B cells contribute to shaping the DLBCL immune environment is unclear. Ad…
Active NIH Awards
- 5R01CA273241-04: Integrative approach to identify genomic features that shape the immune landscape and predict immunotherapy response in diffuse large B cell lymphoma (2026)
- 5R01CA273241-03: Integrative approach to identify genomic features that shape the immune landscape and predict immunotherapy response in diffuse large B cell lymphoma (2025)
- 5R01CA273241-02: Integrative approach to identify genomic features that shape the immune landscape and predict immunotherapy response in diffuse large B cell lymphoma (2024)
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