Mimee Lab
Principal Investigator: Mark Mimee
Institution: University of Chicago (Chicago, IL)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Microbial Engineering to Control the Structure and Function of the Gut Microbiome SUMMARY The human microbiota, the collection of microbes that live on and in the body, is fully integrated with human physiology and has been extensively implicated in health and disease. As with all microbial communities, the summation of environmental, interbacterial, and interkingdom interactions governs both the composition and function of the microbiota. To date, top-down approaches have been largely used to study microbiome function, using multi-omics techniques to draw correlations between microbial taxa, genes, and metabolites with functional properties in different environmental conditions. While these studies contribute a rich set of hypotheses, bottom-up approaches are required to causally pinpoint the molecular mechanisms through which microbes interact with their environment, one another, and the host. Synthesis of these mechanistic studies can further enable predictive models that can be leveraged to engineer microbiomes. Through the development and application of novel technologies, the research program described herein aims to predictively engineer ecological responses and metabolic fu…
Active NIH Awards
- 5R35GM147478-05: Microbial Engineering to Control the Structure and Function of the Gut Microbiome. (2026)
- 5R35GM147478-04: Microbial Engineering to Control the Structure and Function of the Gut Microbiome. (2025)
- 5R35GM147478-03: Microbial Engineering to Control the Structure and Function of the Gut Microbiome. (2024)
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