Rebay Lab
Principal Investigator: Ilaria Rebay
Institution: University of Chicago (Chicago, IL)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Accepting PhD Students
Research Focus
PROJECT SUMMARY This proposal is a renewal application for R01 EY012549 entitled "Cell-Cell Signaling in Embryonic and Retinal Development". The question of how complex tissues like the eye achieve the cellular organization and three-dimensional form required for vision is of fundamental importance to understanding both normal developmental progression and disease mechanisms that perturb cell shapes, structures and patterns. A great deal is known about the genetically controlled terminal differentiation programs that produce the specialized cytoskeletal structures, cell-cell junctional adhesions and cell-extracellular matrix contacts unique to each retinal cell type. How the resulting cell shapes, structures and connections introduce physical constraints that influence final organ shape and function is not well-studied. This is particularly critical to a complex organ like the eye, because the organization of its diverse and highly specialized cell types must be precise to support vision. The goal of this proposal is to understand the cellular and tissue-scale properties and interactions that together sculpt the final form of the Drosophila compound eye. The fly retina provides a s…
Active NIH Awards
- 5R01EY012549-21: Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal (2026)
- 5R01EY012549-20: Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal (2025)
- 2R01EY012549-19A1: Cell-Cell Signaling In Embryonic and Retinal Development-Revised Renewal (2024)
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