Gholipour-Baboli Lab
Principal Investigator: Ali Gholipour-Baboli
Institution: University of California, Irvine (Irvine, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Imaging early development of human neural circuits The overall objective of this research is to create new imaging technology that dramatically improves our ability to analyze the development of brain function and functional networks before birth. Functional magnetic resonance imaging (fMRI) provides a unique capability to study neural circuits and brain functional connections in-vivo. Fetal fMRI acquisition and analysis, however, has been hampered by three important challenges: 1) fetal motion disrupts the spatial and temporal continuity of the MRI signal, 2) geometric distortion is exacerbated by the motion of fetal and maternal organs, and 3) the anatomy and function of the developing fetal brain is distinctly different from those of young children and adults, thus current processing pipelines and atlases are inadequate for reliable fetal fMRI analysis. To address these challenges, we pursue three specific aims in this study, that are focused on 1) developing a prospectively motion navigated fetal fMRI acquisition technology, based on fast real-time image processing, that compensates for the fetal head motion and geometric distortions during acquisitions; 2) developing a post-ac…
Active NIH Awards
- 5R01HD109395-05: Imaging early development of human neural circuits (2026)
- 7R01EB032366-04: Enhanced Imaging of the Fetal Brain Microstructure (2025)
- 5R01HD109395-04: Imaging early development of human neural circuits (2025)
- 7R01HD109395-03: Imaging early development of human neural circuits (2024)
- 7R01EB031849-05: Next-generation in-vivo fetal neuroimaging (2024)
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