Siryaporn Lab
Principal Investigator: Albert Siryaporn
Institution: University of California, Irvine (Irvine, CA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary/Abstract The effective treatment of bacterial infections of skin, deep soft tissues and wounds continues to be a major unmet challenge in healthcare settings, especially among patients with chronic diabetes. Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria that are isolated from chronic, non- healing wounds. Antibiotic resistance has arisen in these particular bacteria, causing these infections to become increasingly difficult to treat and giving rise to multi-drug resistant strains, including Methicillin-resistant Staphylococcus aureus (MRSA). The goal of the proposed work is to develop the next generation of antimicrobials for which the design is inspired by a better mechanistic understanding of mammalian antimicrobial defense pathways. We focus our attention on the antimicrobial activities of neutrophil extracellular traps (NETs), which use histones to kill or suppress microbial proliferation. The antimicrobial mechanism of histones has not been understood. The Siryaporn and Gross labs recently reported that the pairing of histones with an additional component found in NETs – the antimicrobial peptide (AMP) LL-37 (cathelicidin) – prod…
Active NIH Awards
- 5R01AI163196-05: Synergistic killing of bacterial pathogens by histones (2026)
- 5R01AI163196-04: Synergistic killing of bacterial pathogens by histones (2025)
- 3R01AI163196-04S1: Synergistic killing of bacterial pathogens by histones (2025)
- 5R01AI163196-03: Synergistic killing of bacterial pathogens by histones (2024)
- 3R01AI163196-02S1: Synergistic killing of bacterial pathogens by histones (2024)
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