Modlin Lab
Principal Investigator: Robert L Modlin
Institution: University of California, Los Angeles (Los Angeles, CA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT Immunologically, the enigma of the granuloma is best reflected in that sterile, bacillus-controlling, and progressive granulomas can coexist in the same lung, with the progressive form ultimately killing the host. This observation is consistent with the modern concept of “concomitant immunity: the paradoxical immune status in which resistance to reinfection coincides with the persistence of the original infection”. Here, we will test the hypothesis that the development of concomitant immunity regulates macrophage differentiation, influencing granuloma formation and ultimately the outcome of the battle between the immune response and the pathogen Mycobacterium tuberculosis. To do so, we will use single cell RNA sequencing and spatial sequencing to map the coordinates of cell populations and antimicrobial mediators in human TB granulomas. We propose the following specific aims: 1) elucidate the cellular and molecular architecture of human pulmonary TB granulomas, 2) investigate the role of macrophage subpopulations that contribute to the antimicrobial response vs. pathogenesis of TB granulomas; and 3) investigate the role of T cell subpopulations in contribut…
Active NIH Awards
- 5R01AI166313-05: Dynamics of the cellular and molecular architecture of human pulmonary TB granulomas (2026)
- 3R01AI166313-05S1: Dynamics of the cellular and molecular architecture of human pulmonary TB granulomas (2026)
- 5R01AI022553-42: Molecular Analysis of Host Immune Response in Leprosy (2026)
- 5P50AR080594-05: Administrative Core (2026)
- 5P50AR080594-05: Acne: a disease of lipid metabolism, microbiome and the immune response (2026)
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