Rando Lab
Principal Investigator: Thomas A. Rando
Institution: University of California, Los Angeles (Los Angeles, CA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY The loss of tissue homeostasis and regenerative capacity with age underlies some of the most challenging health issues in the elderly. A major contributor to age-related declines in the structure and function of many tissues is the loss of stem cell function that occurs during the aging process. To slow, arrest, or even reverse those age-related declines in stem cell function would represent a major therapeutic success based upon advances in both stem cell biology and the biology of aging. The primary focus of this Program is to understand the molecular basis of age-related changes in stem cell function. An underlying premise is that such an understanding will reveal ways to enhance aged stem cell function and tissue repair. Based on many studies, including innovative work from the laboratories of this Program, there is increasing evidence of dysfunctional genetic, epigenomic, transcriptional, and metabolic changes in stem cells with age. A central concept that is woven throughout this Program is that systemic factors may mediate some of these changes, and that, conversely, cell-extrinsic influences may restore youthful properties to aged stem cells. Another unifying concep…
Active NIH Awards
- 5P01AG036695-14: Molecular Regulation of Stem Cell Aging (2026)
- 5R01AG082764-04: Genomic Instability as A Driver of Stem Cell Exhaustion (2026)
- 5P01AG036695-14: Molecular Regulation of Stem Cell Aging (2026)
- 5P01AG036695-14: Molecular Regulation of Stem Cell Aging (2026)
- 5P01AG036695-13: Molecular Regulation of Stem Cell Aging (2025)
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