Gardner Lab
Principal Investigator: Brooke Meghan Gardner
Institution: University of California, Santa Barbara (Santa Barbara, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Title: Investigating the mechanisms of peroxisome homeostasis Abstract The overarching goal of my lab is to understand how cells make and maintain peroxisomes, a ubiquitous membrane-bound organelle that harbors specialized metabolic reactions. Peroxisomes are both versatile and dynamic: cells use them to adapt to their environment, and thus can rapidly remodel their peroxisomes by altering enzyme content, morphology, and number through peroxisome-specific autophagy and de novo biogenesis. Approximately 35 Pex proteins are known to contribute to peroxisome formation and maintenance, yet the mechanisms by which they act are not resolved at a molecular level. Furthermore, we are likely missing many important players, especially in human cells, and this lack of basic mechanistic knowledge hinders our understanding of how peroxisome contribute to human health, both in rare, genetic Peroxisome Biogenesis Disorders (PBDs), and during the aging process. Our approach is to use techniques in protein biochemistry and yeast cell biology to dissect the mechanism of the Pex proteins, particularly focusing on the AAA-ATPase Pex1/Pex6. We aim to identify the full repertoire of Pex1/Pex6’s endogeno…
Active NIH Awards
- 5R35GM146784-05: Investigating the mechanisms of peroxisome homeostasis (2026)
- 5R35GM146784-04: Investigating the mechanisms of peroxisome homeostasis (2025)
- 5R35GM146784-03: Investigating the mechanisms of peroxisome homeostasis (2024)
- 3R35GM146784-03S1: Investigating the mechanisms of peroxisome homeostasis (2024)
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