Boyd Lab
Principal Investigator: David Fielding Boyd
Institution: University of California, Santa Cruz (Santa Cruz, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Influenza virus infection triggers lung inflammation and pathology and is a leading cause of acute respiratory distress syndrome. Following viral clearance, lung inflammation and pathology can persist preventing recovery from severe cases of infection. Such persistent lung inflammation and pathology, also referred to as Post-viral Lung Disease (PVLD), is an underappreciated aspect of influenza virus infections, even though many patients suffer extended hospital stays, and 25 – 50% of patients continue to experience respiratory symptoms for at least 2 months after hospital discharge. Severe influenza virus infections also exacerbate other chronic respiratory diseases, including COPD and idiopathic pulmonary fibrosis. Currently, there are no approved pharmacologic interventions to improve recovery after viral clearance and to prevent or reverse PVLD and its long-term effects. PVLD is characterized by the persistence of inflammatory immune cells in the lung tissue and the failure of effective alveolar epithelial repair capable of restoring tissue function. The cellular and/or molecular mechanisms driving the persistence of inflammatory immune cells and preventing effec…
Active NIH Awards
- 5R01HL170121-04: Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease (2026)
- 5R01HL170121-03: Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease (2025)
- 5R01HL170121-02: Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease (2024)
Explore 700+ US Biology Labs on FindBioLabs.com