Kim Lab
Principal Investigator: Euiseok J Kim
Institution: University of California, Santa Cruz (Santa Cruz, CA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary Cortico-cortical projection neurons (CCPNs) connect cortical areas with each other to facilitate sensory processing and execute appropriate motor actions. Defects in intra-cortical connectivity are associated with a variety of neural circuit disorders such as dyslexia, autism, and schizophrenia. Because these diseases have genetic components and potentially arise from altered brain development, it is important to understand how CCPNs know which area to target and which synaptic inputs to receive. The long-term goal of my research program is to gain mechanistic insights into cortical circuit assembly at the single cell level in an effort to understand underpinnings of neurodevelopmental disorders and develop new therapies. In doing so, we will be able to identify molecular and genetic mechanisms that link gene expression and neural activity to neuronal connectivity. The objective of this proposal is to identify mechanisms by which long-range cortico-cortical neuronal connectivity is established in the mammalian cortex using the mouse visual system as a model. Our central hypothesis is that V1 neurons, projecting to the AL (anterolateral: V1→AL) or the PM (posteromedi…
Active NIH Awards
- 5R01NS128771-04: Developmental Mechanisms of Fine-scale Cortico-cortical Circuit Formation (2026)
- 5R01NS128771-03: Developmental Mechanisms of Fine-scale Cortico-cortical Circuit Formation (2025)
- 5R01NS128771-02: Developmental Mechanisms of Fine-scale Cortico-cortical Circuit Formation (2024)
- 3RF1MH132591-01S1: Diversity Supplement for a STEM diversity trainee in the lab (2024)
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