Hui Lab
Principal Investigator: Enfu Hui
Institution: University of California San Diego (La Jolla, CA)
Primary Subfield: Immunology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Our lab works at the interface of biochemistry, cell biology, and immunology to understand the fundamental mechanisms of immune checkpoint signaling. Immune checkpoints act as molecular "brakes" that normally restrain immune responses, but tumors can hijack these pathways to escape immune destruction. We combine cell-free reconstitution, live-cell imaging, and cell-based assays to define how immune checkpoints operate at the molecular and cellular levels.
Active NIH Awards
- 5R37CA239072-07: Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions (2025)
- 4R37CA239072-06: Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions (2024)
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