Jin Lab
Principal Investigator: Yishi Jin
Institution: University of California San Diego (La Jolla, CA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary The goals of my research program are to elucidate fundamental mechanisms underlying synapse and axon development and maintenance. We take multi-tiered approaches to investigate these processes, primarily using C. elegans because this animal model is well suited for in vivo imaging with high cellular resolution and because mechanistic dissection is within physiological relevant contexts and coupled with functional impacts. We examine the C. elegans locomotor circuit, because we can unambiguously observe the stereotyped patterns of synapses in all developmental stages, an essential readout to assess how synapses are dynamically regulated. We have consistently developed innovative technologies enabling visualization of organelles and subcellular structures in axons and synapses for in vivo analyses of dynamic cellular processes. We were the first to visualize synapse remodeling of juvenile motor circuit in living animals, which set two decades of vibrant research that have revealed multiple pathways coordinating temporal events and spatial organization of synaptic connections. We established C. elegans axon regeneration model, and have used large-scale genetic screens…
Active NIH Awards
- 5R35NS127314-05: Molecular genetics of axon and synapse development and maintenance (2026)
- 5R35NS127314-04: Molecular genetics of axon and synapse development and maintenance (2025)
- 5R35NS127314-03: Molecular genetics of axon and synapse development and maintenance (2024)
- 3R35NS127314-03S1: Molecular genetics of axon and synapse development and maintenance (2024)
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