Pekkurnaz Lab
Principal Investigator: Gulcin Pekkurnaz
Institution: University of California San Diego (La Jolla, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary/Abstract Every cell must constantly monitor its energy level and appropriately adjust energy generation rates, based on metabolic demand to maintain homeostasis. Continuous fulfillment of this energy demand depends on sufficient nutrient supply, sensing nutrient availability, metabolizing and converting into chemical energy. In eukaryotic cells energy, in the form of ATP, is mainly produced by mitochondria. Not only how much total ATP is generated, local energy level is also important for cells to carry out critical functions, such as neuronal activity, cell migration, tumor cell invasion, wound healing, and immunity. Intracellular transport and positioning of mitochondria shape spatiotemporal heterogeneity in ATP distribution. My overall goal is to understand the molecular pathways regulating the interplay between cellular metabolism, mitochondrial positioning and function. The estimated mitochondrial protein number is ~1,300 for mammalian cells. Post- translational modifications can further magnify the functional diversity of proteins. Metabolic flux- sensitive post-translational modification, O-GlcNAcylation, uniquely couple nutrient status to cellular metabolism…
Active NIH Awards
- 5R35GM128823-09: Metabolic Regulation of Mitochondrial Function (2026)
- 5R01NS136048-03: Defining the metabolic principles of neuronal network oscillations (2026)
- 5R01NS136048-02: Defining the metabolic principles of neuronal network oscillations (2025)
- 5R35GM128823-08: Metabolic Regulation of Mitochondrial Function (2025)
- 5R35GM128823-07: Metabolic Regulation of Mitochondrial Function (2024)
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