Glass Lab
Principal Investigator: Hannah Cranley Glass
Institution: University of California, San Francisco (San Francisco, CA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Neonatal seizures due to brain injury (acute symptomatic seizures) are associated with high risk of post- neonatal epilepsy. Although clinical risk factors can help predict which children are at highest risk for epilepsy, little is known about how genetic factors modify the risk for epilepsy after acute symptomatic neonatal seizures. The proposed “Neonatal Seizure Registry – GENetics of Epilepsy (NSR-GENE)” study will test the central hypothesis that children who develop post-neonatal epilepsy are more likely to have pathogenic variants in epilepsy genes, and enrichment in single nucleotide polymorphisms within key inflammatory, neurotransmitter transport and homeostasis, and neurotrophic gene pathways as compared with children who do not develop unprovoked seizures before age five years, and that these can be added to traditional clinical risk factors to predict epilepsy after neonatal seizures. This observational study leverages the infrastructure of the nine center Neonatal Seizure Registry, to which we have recruited >300 children with acute symptomatic neonatal seizures (NCT02789176, NCT04337697). This unique cohort of children and their parents will be invited…
Active NIH Awards
- 5R01NS124051-05: NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy) (2026)
- 2R56NS111166-05A1: NSR-SLEEP (2026)
- 5R01NS124051-04: NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy) (2025)
- 5R01NS124051-03: NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy) (2024)
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