Gorno Tempini Lab
Principal Investigator: Maria Luisa Gorno Tempini
Institution: University of California, San Francisco (San Francisco, CA)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY—Language and Emotions: Discovery and Clinical Translation (Project ൬) In primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD), symptoms can reflect the neurodegeneration of language and emotion brain networks. Although recent clinical and basic science evidence suggests there is substantial conceptual, mechanistic, and clinical overlap between the domains of language and emotion, research on these areas has largely proceeded in parallel. In patients who exhibit early alterations in both language and behavior, diagnostic accuracy can be limited because theoretical and anatomical models of the language-emotion interface are lacking. A central hypothesis of this proposal is that damage and decline in interacting language and emotion neural networks underlie symptoms in PPA, bvFTD, and emotional semantic variant frontotemporal dementia (esvFTD), a newly defined syndrome. Studies of PPA and bvFTD often do not include comprehensive assessments of both language and emotion systems because evaluation of these domains typically requires specialized, time-intensive approaches. A more detailed understanding of the clinical features that char…
Active NIH Awards
- 5P01AG019724-24: Frontotemporal Dementia: Genes, Images, and Emotions (2026)
- 5P01AG019724-24: Biospecimens (2026)
- 5P01AG019724-24: Administration (2026)
- 5P01AG019724-24: TDP-43 Loss-of-Function: Biology to Biomarkers (2026)
- 5P01AG019724-24: Language and Emotions: Discovery and Clinical Translation (2026)
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