Marshall Lab
Principal Investigator: Wallace Marshall
Institution: University of California, San Francisco (San Francisco, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Abstract Cells are highly complex living nanomachines with beautiful structures of great precision. This is true not only for free living organisms like ciliates or radiolarians, but also for cells inside the human body. These complicated structures are directly linked to the physiological functions of cells, and alterations in cell geometry are a hallmark of many disease states. Yet in most cases we have almost no information about how cells determine their geometry at the level of organelle size and shape. Thus, understanding the origins of cell geometry remains a fundamental unsolved problem in cell biology. Part of the challenge is that cell geometry involves multiple spatial scales ranging from molecules up to the whole cell. Spanning this gap between scales requires us to go beyond traditional molecular biology approaches and bring in methods from physics and engineering. For this reason my proposal is based on an integrated combination of approaches, using several different model organisms and cell types to address the origins of cell geometry at several different size scales. At the level of single organelles, I will continue to probe the mechanism of flagellar length contr…
Active NIH Awards
- 5R35GM130327-08: Origins of Cell Geometry (2026)
- 5R35GM130327-07: Origins of Cell Geometry (2025)
- 3R35GM130327-06S1: Origins of Cell Geometry (2025)
- 3R35GM130327-07S1: Origins of Cell Geometry (2025)
- 2R35GM130327-06: Origins of Cell Geometry (2024)
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