Yokoyama Lab
Principal Investigator: Jennifer S Yokoyama
Institution: University of California, San Francisco (San Francisco, CA)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY—Genetics Core (Core F) Mendelian mutations, common risk factors, and – more recently – rare risk-associated variants have been identified in neurodegenerative diseases. Yet, a significant proportion of the heritability for Alzheimer's disease (AD) and frontotemporal dementia (FTD) remains unexplained, suggesting that additional genetic risk factors await identification. This PPG Genetics Core has supported PPG investigators over the past ൭൫ years by ൬) collecting and storing DNA and RNA samples from the entire PPG cohort; ൭) providing genetic testing for known pathogenic causes of dementia and risk-associated variants, using both traditional and next-generation sequencing methods; ൮) contributing to the discovery of novel genes and novel risk-associated variants through data generation and case-based screening, using genetic and genomic approaches; and ൯) establishing an informatics platform to facilitate data sharing, storage, and mining, including access to dedicated computational and storage resources. In this renewal application, we propose to leverage this infrastructure and expertise to expand the portfolio of genetic and genomics assays available to the PPG.…
Active NIH Awards
- 5P01AG019724-24: Genetics (2026)
- 1R01AG096763-01: Blood-based genomics, transcriptomics, and immune responses in early-onset AD (2026)
- 5P30AG062422-08: Core G - Biomarker Core (2026)
- 5P01AG019724-23: Genetics (2025)
- 5U54NS123985-05: Core C: Genomics and Transcriptomics (2025)
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