Bradburd Lab
Principal Investigator: Gideon Bradburd
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary In humans, genetic variation is distributed geographically, reflecting the history of human movements across the continents. Understanding these spatial patterns is crucial for many fields in human population genomics, including the study of human evolutionary history and linking genotypes and phenotypes. Historically, limitations in the size and scope of empirical datasets have allowed researchers to employ models that ignore geography, but modern genomic datasets demand population genetic methods that incorporate geographic space. The failure to consider geography in population genetics has significant consequences, from incorrect inference of population structure to misleading conclusions in genome-wide association studies. Over the past five years since beginning this R35, we have developed and applied multiple new statistical meth- ods to understand the role of geography in structuring patterns of genetic diversity and relatedness. We have focused on the inference of important population genetic parameters, such as population dispersal and density, as well as on methods for recovering the geographic history of large-scale population movements. The flexibility o…
Active NIH Awards
- 2R35GM137919-07: Incorporating geography into statistical methods for analysis of population genomic DNA (2026)
- 5R35GM137919-06: Incorporating geography into statistical methods for analysis of population genomic DNA (2024)
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