Chandrasekaran Lab
Principal Investigator: Sriram Chandrasekaran
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Synthetic Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
My lab develops systems biology models of metabolic regulation and applies these for drug discovery. The impact of cellular metabolism on drug response has been observed in a wide range of diseases. However, how metabolism influences the activity of diverse classes of drugs has not been systematically explored. This has been a challenge due to the impact of metabolism on numerous cellular processes. To address this, over the past 5 years, my lab has developed several new systems biology models that simulate the impact of metabolic heterogeneity and regulation on drug response using multiomic data. During the next phase of this R35, we will focus on expanding our models to incorporate metabolic regulation by signaling networks, non-coding RNAs, DNA methylation and splicing. In addition, we will also develop methods to incorporate multiscale behavior and spatial-temporal heterogeneity from spatial imaging and single-cell omics datasets. This will be achieved using an innovative combination of new technologies including genome-scale modeling, machine learning, single-cell and spatial omics. We will use these models to predict the impact of metabolic activity on drugs that inhibit dive…
Active NIH Awards
- 5R35GM137795-07: Linking metabolic activity with drug sensitivity using metabolic influence networks (2026)
- 2R35GM137795-06: Linking metabolic activity with drug sensitivity using metabolic influence networks (2025)
- 5R35GM137795-05: Linking metabolic activity with drug sensitivity using metabolic influence networks (2024)
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