Chen Lab
Principal Investigator: Yuqing Eugene Chen
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT The goal of this R01 proposal is to advance our understanding of the genetic regulatory mechanisms underlying the newly identified loci associated with abdominal aortic aneurysms (AAA), with the ultimate goal of enabling earlier prevention and treatment of the disease. Our research team comprises individuals from multiple areas of medical research, including high-throughput genetics, computational and statistical genetics, and cardiovascular disease biology. Building upon our past research endeavors centered on coronary artery disease and myocardial infarction, our focus is now to uncover the biological mechanisms that underscore genetic loci linked to AAA, employing a combination of genetics, bioinformatics, as well as cell culture and animal models. During the previous funding period, we have played a crucial role in the Million Hearts Initiative, Global Biobank Meta-analysis Initiative (GBMI), Abdominal Aortic Aneurysm Genetics (AAAGen) Consortium, and a substantial collaboration studying the genetics of atrial fibrillation. In this application, we have outlined two specific aims: In Aim 1, we propose to combine the meta-analysis efforts from AAAGen and…
Active NIH Awards
- 5R01HL109946-12: Using genetics to discover mechanisms of abdominal aortic aneurysm (2026)
- 5R24OD039745-02: National Center of Rabbit Models for Translational Research (2026)
- 5R01HL159871-04: Browning of perivascular adipose tissue protects against thoracic aortic aneurysm (2025)
- 5R01HL162294-04: Nitro-Fatty Acids and Cardiovascular Disease (2025)
- 5R01HL109946-11: Using genetics to discover mechanisms of abdominal aortic aneurysm (2025)
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