Ginsburg Lab
Principal Investigator: David Ginsburg
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Our research program centers on the regulation of hemostasis and thrombosis, heavily informed by the study of human patients with associated genetic disorders. The current proposal will continue this work, with a specific focus in four areas: 1) characterization of endothelial cell heterogeneity across diverse vascular beds and its role in the pathogenesis of thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, and other vascular disorders, 2) application of comprehensive deep mutational scanning methods, using von Willebrand factor (VWF) and plasminogen activator inhibitor-1 (PAI-1) as model hemostasis proteins, to guide precision medicine genome sequence interpretation, 3) directed molecular evolution of novel serine protease inhibitor (SERPIN) proteins with unique new properties, providing valuable insight into protein structure/function relationships as well as identifying potential novel therapeutics, and 4) characterization of the full cargo repertoires for the LMAN1 and SURF4 cargo receptors, identifying potential overlapping cargo receptors, and probing unconventional protein secretion, with important implications for disorders of hemostasis…
Active NIH Awards
- 5R35HL171421-03: The Molecular Genetics of Hemostasis (2026)
- 5R35HL171421-02: The Molecular Genetics of Hemostasis (2025)
- 1R35HL171421-01: The Molecular Genetics of Hemostasis (2024)
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