Morris Lab
Principal Investigator: Aaron Harvey Morris
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Synthetic Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Regenerating soft tissue is critical for adequate healing after injury across many tissue types, but often does not occur due to inadequate microenvironmental cues. There remains an unmet clinical need to heal chronic wounds, and similar problems exist are ubiquitous across many wound types including: dysregulation of inflammatory processes and insufficient signal from regenerative factors. We propose a research program dedicated to deepening our understanding of chronic wounds and developing translational treatments that centers around four basic questions about reprogramming cellular responses in wound microenvironments: i) how do T-cell phenotypes contribute to inflammatory dysregulation?, ii) can T-cells be reprogrammed to mitigate inflammation and resolve injury?, iii) how does dynamic secretion of alarmin proteins impact healing?, and iv) can we reprogram cellular responses to alarmins to respond with regenerative factors. We know that multiple types of T cells are involved in healing wounds, but it is not clear how they interact and directly influence healing or if reprogramming inflammatory T cells to regulatory ones could improve healing. Furthermore, we know that alarmins…
Active NIH Awards
- 1R35GM162195-01: Reprogramming cells for repair of chronic wounds (2026)
- 1R01AI198663-01: Precision Biomaterials to Monitor Antigen-Specific Cells (2026)
- 3R00EB028840-05S2: Supplement to Immunological Niches and Noninvasive Biosensors for Autoimmune Monitoring (2025)
- 5R00EB028840-05: Immulogical Niches and Non-invasive Biosensors for Autoimmune Monitoring (2024)
- 3R00EB028840-05S1: Immulogical Niches and Non-invasive Biosensors for Autoimmune Monitoring (2024)
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