Yang Lab
Principal Investigator: Qiong Yang
Institution: University of Michigan (Ann Arbor, MI)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary Biological oscillators are essential to a variety of cyclic processes in cells and development. These include cell divisions, heartbeats, and somitogenesis. Impaired biological oscillators may cause diseases from insomnia to cancer. It is thus crucial for an oscillator to develop the ability to maintain a stable function against the changes in environmental conditions. The architecture of many oscillators is highly conserved among species, despite that the actual molecules may vary from species to species. This highlights the important role of network topology in the functions of biological oscillators. How the network structure is linked to the certain functions of biological oscillators is still an open challenging question in systems and synthetic biology. The goal of this proposal is to identify the fundamental principles underlying the robust functioning of clock networks. To achieve the goal, a systematic computational approach will be applied to analyze all topological modifications that significantly impact the robustness and tunability of clock networks. As a comparison to computational studies, this proposal will experimentally investigate the possible mec…
Active NIH Awards
- 5R01GM144584-04: Understanding the robustness of cell cycles (2026)
- 5R01GM144584-03: Understanding the robustness of cell cycles (2025)
- 5R01GM144584-02: Understanding the robustness of cell cycles (2024)
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